Les pesticides

Les insecticides ou pesticides, tableau 2


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Classe
de pesticide
macrophages
lymphocytes T
ou B
mastocyte
ou "mast cells"
granulocytes
moelle osseuse, thymus
et autres...
15.- Biscarbamates (BCA):
Thiocarbamates ou dithiocarbamates
thirame
ferbame
Ziram
1.- DATA SHEETS ON PESTICIDES No. 71 (INCHEM)fongicide, mutagène, terratogène, puissant neurotoxique (destructeur des axis avec calcification en présence de macrophages).
2.- thiophanate-methyl (Topsin M) Pesticide Tolerance 7/02: LOAEL = 0.0151 mg/L (sur 14 jours), fondé sur l'incidence croissante des macrophages alvéolaires, hyperplasie à pneumonocyte du poumon et alvéolite non suppurative.
1.- Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.
2.- Middle Tennessee Division of the Tennessee Academy of Science - 2003 Meeting: Inhibition de la fonction immunisée des cellules tueuses naturelles humaines suivant l'exposition in vitro au fongicide agricole, ziram.
1.- INCLUSION OF CHEMICALS IN THE INTERIM PRIOR INFORMED CONSENT PROCEDURE - REVIEW OF PROPOSALS FOR SEVERELY HAZARDOUS PESTICIDE FORMULATIONS (ONU): présomptions de liens morbides entre plusieurs pesticides (Thirame 15% + Benomyl 7% + Carbofuran 10%, Fenitrothion, Phosphine and Propoxur) et des cas de morts mytérieuses.
2.- Latex (Thiram)
1.- Decreased counts of blood neutrophils, monocytes, and platelets in human immunodeficiency virus-infected children and young adults treated with diethyldithiocarbamate.
2.- Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper.
16.- Carbamates (CAR).

Sur le moteur d'Inchem: 226 documents consultables.
1.- Carbaryl(cf, p2)
2.- Inhibition of nuclear factor-kappaB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy.
1.- Carbaryl(cf,p2)
2.- Immunotoxicological tests
3.- Why Canadian Physicians are Concerned about the Policies Regulating Pesticide Use: ...T-cells react abnormally...
1.- Recommandations pour la prévention de l'allergie due au port de gants en latex
2.- Latex (carbamates)
1.- Cabaryl Part 1 et Part2 carcinogène.
2.- Effects of Pesticides on the Immune System: Des carbamates sont connus pour causer les changements immunitaires [ 23 ], aussi bien que les composés arsenicaux [ 401, et les mitocides tels que chlorobenzylate [ 41 ] et Milbex [ 41 ].
17.-Chlorophénols (CPH).
1.- PIGMENTED MACROPHAGE AGGREGATES: A TOXIC RESPONSE IN FISH EXPOSED TO BLEACHED-KRAFT MILL EFFLUENT?
2.- 2,4,6-TRICHLOROPHÉNOL- fiche INERIS(cf p. 12)
3.- Public Health Goal for PENTACHLOROPHENOLin Drinking Water cf page 11.
1.- PCBs & Immune Deficiency Disease. Extrait: Des produits chimiques tels que les acides phénoxyacétiques, les chlorophénols, les dioxines, les dissolvants organiques, les diphényles polychlorés, le chlordane, et les drogues immunosuppressives ont été associés au Lymphome autre que celui de Hodgkin.
2.- TOXICOLOGICAL PROFILE FOR PENTACHLOROPHENOL Fiche ATSDR (cf pages 37 et 46) dont extrait: ...Le contrôle comparatif de personnes exposées aux pentachlorophénol indique que ceux exposés avaient activé lymphocytes T, autoimmunité, immunosuppression, et dysrégulation des lymphocytes B...
1.- Engaging with Multiple Chemical Sensitivity (MCS)- London 2003: Les chlorophenols mis en cause dans la MCS (Multiple chemical sensitivity dont les processus sont détaillés), (incinérations avec création de dioxines)
2.- Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro
1.- Pesticides and Lymphoma
2.- CHLOROPHENOLS A-5 -MINIMAL RISK LEVEL (MRL) WORKSHEET (ATSDR): 2,4-Dichlorophenol, hyperplasie de la moelle osseuse et nécrose hépatique.
3.- PESTICIDE RESIDUES IN FOOD - 1981- INCHEM: précurseur du trichlorophénol, l’acide 2,4,5-trichlorophénoxyacétique (2,4,5-T) 4.- CHLOROPHENOLS.
18.-Chroménones (CHR).
1. - Diels–Alder reactions in water
 Pas de données publiées

1. - Communications protégées sur quatre
2.- traduction françaisethème de recherche d'un étudiant en informatique
1.- combinaisons anti HIV sur la page WEB"NIAID - Division of AIDS"
2.- Synthesis and Biological Screening of 7-Hydroxy-4-Methyl-2H-Chromen-2-One, 7-Hydroxy-4,5-Dimethyl-2H-Chromen-2-One and their Some Derivatives: haut degré d'activité cytotoxique et bactéricide.
3.- 1.- 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2.-Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).: antipsychotique potentiel atypique.
4.- Toute nouvelle cible anti-cancer: Receptor-based design of protein kinase CK 2 inhibitors from the combinatorial library of 4H-4-chromenones
19.- Cyclohexanedione-oximes (CYO).
 Pas de données publiées
Le 1,3-cyclohexanedione est très utilisé pour contrôler la repopulation du foie par les
   
hépatocytes après transplantation de moelle osseuse. Sur ce sujet, voir par exemple:
1.- TYROSINE CATABOLIC PATHWAY
2.- Blood into Liver: Miracle, Bio Revolution, Clinical Promise—or All Three?
    Pas de données publiées

Immunité:
20.- Diazines
(DIA).
1.- Carbohydrate Hydrazones and Osazones as Organic Raw Materials for Nucleosides and Heterocycles à compléter par
2.- Carbohydrate Based Vaccines.(utiliser au besoin GOOGLE en cache)
3.- Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E1-mediated metabolic activation
4.- Effect of various potential inhibitors, activators and inducers on the N-oxidation of isomeric aromatic diazines in vitro using rabbit liver microsomal preparations (cliquer sur 10438)
21.- Dithiocarbamates (DTC).
 Traité avec les carbamates (16)
22.- Guanidines
(GUA). Appartient à la famille des anti H2 (Cimétidine, Famotidine...).

Cette famille se prête à des millions de combinaisons

Voir aussi Imidazoline
Relationship between imidazoline/guanidinium receptive sites and monoamine oxidase A and B.
1.- In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection (Utiliser GOOGLE pour accéder à cet article)
2.- First Non-α-Amino Acid Guanidines Acting as Efficient NO Precursors upon Oxidation by NO-Synthase II or Activated Mouse Macrophages (CNRS France)
3.- Isoform-Selective Substrates of Nitric Oxide Synthase
et de nombreuses autres études à trouver sur GOOGLE
1.- The I -imidazoline receptor in PC12 pheochromocytoma cells reverses 1 NGF-induced ERK activation and induces MKP-2 phosphatase
2.- In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection.
3.-PC121/2003_PC121_Guy_LectureNotes.pptL'auteur a omis de donner un titre à cette étude aveuglante de clarté et d'illustrations!
Sur le mastocyte intestinal: 1.- Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats. (Réaction inconnue de bon nombre de médecins français)
2.- Synthesis and pharmacological activity of fluorescent histamine H(2) receptor antagonists related to potentidine
Sur les reins: In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection.
Sur les allergies aux gants médicaux: synthèse "GLOVE - ASSOCIATED REACTIONS"
Lymphocytes T et Guanidines: In Vivo Protein Binding and Functional Analysis of cis-Acting Elements in the U3 Region of the Bovine Leukemia Virus Long Terminal Repeat
Interactions au niveau rénal: Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines
Traitement et prévention du diabète et de certaines complications: 1.- Advanced Glycosylated End Products and Hyperglycemia in the Pathogenesis of Diabetic Complications
2.- Relationship between imidazoline/guanidinium receptive sites and monoamine oxidase A and B.
3.-Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines having Electron-Withdrawing Substituents
23.- Huiles minérales et végétales (HUI).
 Cliquer sur ce lien pour consulter le tableau
24.- Hydrocarbures (HYD).(sauf chlorés)
 Cliquer sur ce lien pour consulter le tableau
25.-Hydrocarbures halogénés (HYH).
Fluorométhanes et Fluoroéthanes
Pas de données scientifiques sanitaires publiées
alkyl bromides
 Pas de données pertinentes publiées
1.- Designing surfaces that kill bacteria on contactPoly:
Poly(4-vinyl-N-alkylpyridinium bromide) was covalently attached to glass slides to create a surface that kills airborne bacteria on contact.
2.- Bromomethane (CASRN 74-83-9): carcinogenèse et mutagènèse possible en présence de bromides organiques.
3.- Nomination of 1-Bromopropane (1-BP) and 2-Bromopropane (2-BP) for Testing by the National Toxicology Program: histopathological damage was found in several tissues (testis, bone marrow, brain...).
4.- Histopathologic Findings of Bone Marrow Induced by 2-Bromopropane in Male Rats
   • 2,3-dibromobutane
   • 2-bromobutane
Pas de données pertinentes publiées
2-bromo-2-methylpropane
Pas de données partinentes publiées
SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 (PROPOSITION 65): carcinogène possible
1,2-DIBROMO-3-CHLOROPROPANE
additif de nourriture, et de tabac (bromides chlorés)

métabolites:
3-chloro-1,2-propanediol (alphachlorohydrin), and oxalic acid

voir également List of Drinking Water Contaminants & MCLs
1.- SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS 1,3-DICHLORO-2-PROPANOL 2.- Report on "Pulmonary Adenocarcinoma - A Review of Pathogenesis and Clinical Aspects"
Pas de données spécialement pertinentes
  • Federal Attention to Pulmonary Toxicants: cf page 10, rechercher
1,2-DIBROMO-3-CHLOROPROPANE.
  •Toxicological Characteristics of Endocrine-Disrupting Chemicals: Developmental Toxicity, Carcinogenicity, and Mutagenicity
  •Single-strand breaks, cell cycle arrest and apoptosis in HL-60 and LLCPK1 cells exposed to 1,2-dibromo-3-chloropropane.
  •ATSDR: TOXICOLOGICAL PROFILE FOR 1,2-DIBROMO-3-CHLOROPROPANE: (p.71) ..."reversible atrophy and depletion of lymphocytes in the thymus, spleen, and lymphatic nodules were reported in rats after a single subcutaneous injection..."
  • Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion (cf page 4)
  • Effect of Oxygen on the Dehalogenation of 1,2-Dibromo-3-Chloropropane by Cytochrome P450cam (CYP101)
  • An update of the National Toxicology Program database on nasal carcinogens. (thème à rechercher): "12 chemicals were identified that produced nasal tumors: allyl glycidol ether, p-cresidine, 1,2-dibromo-3-chloropropane, 1,2-dibromoethane, 2,3-dibromo-1-propanol, dimethylvinyl chloride, 1,4-dioxane, 1,2-epoxybutane, iodinated glycerol, procarbazine, propylene oxide, and 2,6-xylidine"
  • Sur PUB MED: Caractères toxiques, mutagènes, carcinogènes, ...rassemblant plus de 200 publications sur le dibromochloropropane
  • Health Effects of Drinking Water Contaminants1 (rechercher DBCP).
1,3-DICHLOROPROPENE
1.- The chronic toxicity and oncogenicity of inhaled technical-grade 1,3-dichloropropene in rats and mice.
1.- Hazardous Air Pollutants and Asthma (cf commentaires des illustrations page 3 et table 1 page 2)
2.- Health effects from stratospheric ozone depletion and interactions with climate change
————————––––
  • Federal Attention to Pulmonary Toxicants: cf page 10, rechercher 1,3-DICHLOROPROPENE
  • ATSDR:TOXICOLOGICAL PROFILE FOR 1,3-DICHLOROPROPENE:
  • ISOMERIC EFFECTS ON THIOSULFATE TRANSFORMATION AND DETOXIFICATION OF 1,3-DICHLOROPROPENE
  • TOXICOLOGICAL REVIEW OF 1,3-DICHLOROPROPENE (IRIS): affecte le thymus et la moelle osseuse
26.- Indanediones (IND).

molécules ayant comme structure de base un noyau benzénique fusionné à un cyclopentane
1.- Toxicant, rechercher "Indanediones" ou "Anticoagulant rodenticides"
2.- Utilisation possible comme médicament: ANTICOAGULANT RODENTICIDE TOXICITY, sur le journal WEB VRCC Post PUBLISHED BY THE VETERINARY REFERRAL CENTER OF COLORADO.
1.- Miradon Side Effects, Interactions, Reactions, Pediatric, Geriatric - Anisindione
2.- RxPG: Forums Les indanediones sont fréquemment utilisés comme poisons anticoagulants contre les rats et souris.
27.-Inorganiques (INO).
Les effets sanitaires des composés inorganiques
ATTENTION! Les composés mercaptiques font partie des composés inorganiques mais exercent des effets internes qui ressortisent directement de désordres endogènes mortels du métabolisme!
28.- Nitrobenzènes (NBZ).
Composé benzénique doté d'un radical nitro (NO2), (réaction du benzène en présence d'acide sulfurique et d'acide nitrique)(slide nitration of benzene de la page Reactions of Aromatic Compounds)
Synthèse sous l'action des ultra-violets (cf. fig.1)

  • Sur la nomenclature des aromatiques consulter la page Web nomenclature

  • 25 fiches sur le moteur ILO (OIT)
  • 63 documents sur le moteur IPCS d'INCHEM
  • 226 documents sur le moteur de recherche de l'USEPA
  • 5 études et 3 ToxFAQs sur le moteur de l'ATSDR
1.- Toxicity Summary for NITROBENZENE (ATSDR): extrait: "... Splenic lesions, such as sinusoidal congestion, increased extramedullary hematopoiesis, hemosiderin-laden macrophages, infiltration of red pulp, and presence of proliferative capsular lesions, were present to varying degrees in all three species and exposure groups..."
2.-NITROBENZENE (Inchem) Extrait: "...Histopathological findings at the low dose included an increased incidence of secretory product in respiratory epithelial cells; degeneration/loss of olfactory epithelium; dilation of submucosal glands and accumulation of brown pigment-containing macrophages in the submucosal areas of olfactory epithelium; bronchiolization of alveolar cell walls..."
1.- Immune Study Reviews 23-45"...Descriptions were offered of natural tumor resistance effectors, including natural killer or cytotoxic cells and macrophages, and acquired resistance effectors, including cytotoxic T-lymphocytes and macrophages activated by antibody dependent cellular cytotoxicity or by macrophage activation factor... Chemicals and metals which have been shown to alter tumor transplantation resistance in mouse models include arsenic (7440382), cadmium (7440439), chromium (7440473), cyclophosphamide (50180), diethylstilbestrol (56531), dieldrin (60571), 7,12-dimethylbenzanthracene (57976), hexachlorobenzene (118741), lead (7439921), nitrobenzene (98953), ..."
2.- Acute immunotoxicity of p-chloronitrobenzene in mice: II. Effect of p-chloronitrobenzene on the immunophenotype of murine splenocytes determined by flow cytometry
1.- The Chemokine RANTES Is a Crucial Mediator of the Progression from Acute to Chronic Colitis in the Rat
2.- Synthesis and Physiological Activity of Novel Tocopheryl Glycosides
1.- NITROBENZENE (Inchem)"...Clinical signs included ataxia, lethargy, dyspnoea, convulsions, irritability and rapid head-bobbing movements. Liver weight in treated mice was increased compared with controls; the increase was statistically significant at the two highest doses in males and at all doses in females. Fatty change was reported in the X-zone (basophilic cells that surround the medulla around 10 days of age, then gradually disappear as mice mature) of the adrenal glands of 8 of 10 high-dose female mice...." (Atteintes du cerveau -démyélination,-dans tous les cas de figure d'exposition et atteinte du foie)
"...The presence of pigment in the spleen, liver and kidney was considered to be secondary to the methaemoglobinaemia and anaemia and subsequent red blood cell breakdown...
2.-Exemples de toxicité: NTP technical report on the toxicity studies of 2-Chloronitrobenzene (CAS No. 88-73-3) and 4-Chloronitrobenzene (CAS No. 100-00-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice
3.- Bone marrow failure: "...Chloramphenicol is a nitrobenzene compound, thus belonging to a class known to be marrow toxic..."
29.- Organochlorés (ORC).

Le chlore et ses innombrables composés.
Les composés chimiques du chlore et leurs effets sont tels que GOOGLE les a rassemblés dans une même rubrique.

  • Les PCB et autres dioxines font partie de la famille!

  • What Are Organochlorines? And Why Are They So Dangerous?
  • Organochlorines in Tursiops Truncatus Milk Collected at Varied Stages of Lactation
1.- 1.- CHEMICAL SUMMARY FOR CHLORINE prepared by OFFICE OF POLLUTION PREVENTION AND TOXICS U.S. ENVIRONMENTAL PROTECTION AGENCY (August 1994).
2.- Pathology of fathead minnows (Pimephales promelas) exposed to chlorine dioxide and chlorite
3.- Is Menstruation Obsolete?: Profet noted at the outset that menstrual blood differs in composition from that of regular blood, most notably by containing immune cells called "macrophages"....Houppert collates health studies conducted on toxic shock syndrome and other reproductive health problems (including infertility and endometriosis) and finds that much of these ailments may be directly caused by even trace levels of dioxins found in most tampons and pads --the chlorine compounds that make our "sanitary protection" whiter than white.
4.- Morphofunctional characteristics of alveolar macrophages under the effect of a toxic factor
1.- Fundamentals of Environmental Toxicology.- Immunotoxicity: "...The seals that were fed contaminated Baltic herring developed significantly higher body burdens of potentially immunotoxic organochlorines and displayed impaired immune responses as demonstrated by suppression of natural killer cell activity and specific T-cell response
2.- 23 Studies of PCB Effects and Human Immune System Disorders: un bilan qui laisse stupéfié devant l'indifférence des responsables politiques du Monde entier!...
3.- Fact Sheets. Immune System: "...Children and adolescents exposed to PCBs and PCDFs in Taiwan through consumption of contaminated rice oil (YuCheng disease) exhibited decreased serum IgA, IgM, cytotoxic T cells and suppressor T cells with cell-mediated immune system dysfunction..."
4.- IMMUNOTOXICOLOGY HEALTH EFFECTS REVIEW (Volume 2 Issue 2 January-March 1997): un document court mais clair qui montre que ce qui se passe dans la mer concerne déjà toute l'Humanité...
1.- Environmental Medicine, Part 1: The Human Burden of Environmental Toxins and Their Common Health Effects: lire notamment le paragraphe "Adverse Immune Effects of Environmental Pollutants (Immunotoxicity)"
2.- Engaging with Multiple Chemical Sensitivity (MCS)- London 2003: ce document très bien illustré dégage quatre types d'hypersensibilité multiple -[Multiple chemical sensitivity ou MCS] (dont l'existence est en général niée et donc non enseignée dans la plupart des Facultés de médecine françaises, ce qui explique les conclusions du rapport de l'INSERM sur le syndrome de la Guerre du Golfe). Extrait: d.Essentially, chemical irritants bind to receptors on unmyelinated sensory nerve C-fibres which are found in the gut, airways, eye and genitourinary system and are more numerous in patients with MCS. Binding triggers the release of substance P (for pain) and other mediators of inflammation by interaction with mast cells, Figure 3 ...
1.- Bacterial glutathione: a sacrificial defense against chlorine compounds.
2.- Prostaglandins, Enzymes and Cells- Toxins and Cell Function (rôle biologique des organochlorines dans la genèse de l'asthme).
3.- CROMOGLYCATE: A HEALING AGENT IN ACUTE CHLORINE-INDUCED LUNG DAMAGE
4.- Endometriosis Caused by Organochlorines.
5.- Adipose Tissue Levels of Organochlorine Pesticides and Polychlorinated Biphenyls and Risk of Non-Hodgkin's Lymphoma
6.- CARCINOGENESIS: Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway
7.- 1997 Progress Report: Biomarkers for Organochlorine-Associated Immunosuppression in Birds: Field Investigations in the Great Lakes and Laboratory Studies
8.- Pollution with organic tin compounds, organochlorines, hydrocarbons and metals in sediment samples from Guanabara Bay, Rio de Janeiro, Brazil.: donne une ifdée très précise de ce qui attend les prochaines générations d'homo sapiens.
(1) Pathophysiology and Pharmacology of Reactive Oxygen Species (ROS): Comment les polluants s'insèrent en métabolites dans la chaine d'oxygénation des espèces?



dernière mise à jour le 3 août 2004.